秦雯雯,许晓辉,魏蕾蕾,周劝娥,等.抗肿瘤药物药效学的评价方法[J].,2014,1(1):51-54.
抗肿瘤药物药效学的评价方法
Evaluation method for pharmacodynamics of antitumor drug
投稿时间:2013-11-27  最后修改时间:2013-12-01
DOI:
中文关键词:  抗肿瘤药物;药效学 体外筛选;体内筛选 研究趋势
英文关键词:anticancer;drugs pharmacodynamic;in vitro;screening in;vivo screening;research trends
基金项目:
作者单位E-mail
秦雯雯 兰州大学药学院 418439975@qq.com 
许晓辉 平凉市药品检验检测中心 418439975@qq.com 
魏蕾蕾 平凉市药品检验检测中心  
周劝娥 平凉市食品检验检测中心  
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中文摘要:
      抗肿瘤药物的药效学研究是新药发现与开发的重要环节,通常是指从样品到活性检测至动物实验的各个阶段的工作。本文介绍了抗肿瘤药物筛选的分子靶点及其抗肿瘤药物的药效学研究的体外筛选方法和体内治疗作用的动物试验方法,同时总结了抗肿瘤新药药效学评价中需两个问题,展望了抗肿瘤药物药效学研究趋势。
英文摘要:
      The study for Pharmacodynamic of anticancer drug is an important part to new drug discovery and development. which usually refers to the work from the activity detection of sample to the various stages of animal experiments. This article describes the molecular target for anticancer drug screening , the methods pharmacodynamics of anticancer drugs in vitro screening and the animal test methods for therapeutic effects in vivo, at the same time, summarizes two issues about pharmacodynamic evaluation of anti-tumor drugs, prospects research trends of pharmacodynamics of anticancer drug.
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