郭楠楠,李珊珊,张文.血清标志物(NSE,CEA,CA-125,CYFRA21-1)和分子标志物(MDR-1,LRP,RRM-1,EGFR,ERCC-1,BRCA-1)在非小细胞肺癌患者原发灶和转移淋巴结的表达[J].,2014,1(1):24-29.
血清标志物(NSE,CEA,CA-125,CYFRA21-1)和分子标志物(MDR-1,LRP,RRM-1,EGFR,ERCC-1,BRCA-1)在非小细胞肺癌患者原发灶和转移淋巴结的表达
Expression of serum markers (NSE, CEA, CA-125, CYFRA 21-1) and molecular markers (MDR-1, LRP, RRM-1, EGFR, ERCC-1, BRCA-1) in primary sites and metastatic lymph nodes of lung cancer patients
投稿时间:2013-12-08  最后修改时间:2013-12-08
DOI:
中文关键词:  非小细胞肺癌;转移淋巴结 分子标志物;血清标志物
英文关键词:non-small cell lung cancer; metastatic lymph node; molecular markers; serum markers.
基金项目:校级/院级其它项目;其它部级项目
作者单位E-mail
郭楠楠 解放军总医院第一附属医院胸外科 gnn304@163.com 
李珊珊 解放军第309医院西山门诊部  
张文 解放军总医院第一附属医院胸外科 zw928296@163.com 
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中文摘要:
      目的:研究不同血清标志物及分子标志物在肺癌不同病理亚型、原发灶与转移淋巴结间表达的差异。方法:对48例住院接受开胸手术切除原发病灶及转移淋巴结的患者进行4种血清标志物和6分子标记物检测。结果: ERCC-1的表达在原发肿瘤和转移部位间有显著差异(P=0.007);CEA的血清水平在不同肿瘤亚型患者间存在显著差异(P=0.008)。结论:标志物检测对于患者预后的判断及治疗方案具有一定价值。
英文摘要:
      To investigate the different expression of serum markers and molecular markers in the primary tumor and the metastatic lymph nodes of lung cancer patients with four histological subtype. Method: There were 48 cases of lung cander patients who underwent thoracic surgery for removal of primary and metastatic lesions had been enrolled for testing. Result: Expression of ERCC-1 was significantly different in primary tumors and metastatic sites (P=0.007)and the serum level of CEA was significantly different for patients with different cancer subtypes(P=0.008).Conclusion: tumor molecular markers has value to estimate prognosis and select treatments for patients.
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