杨巧红,张新江,杜清,李琳琳,蓝华全,吕依扬,黄舒蕾,印明柱,魏小勇,等.胃癌靶向治疗机制及药物治疗情况的研究进展[J].,2018,5(9):34-42.
胃癌靶向治疗机制及药物治疗情况的研究进展
Study on targeted therapy mechanisms and drug treatment of gastric cancer
投稿时间:2018-08-01  最后修改时间:2018-08-15
DOI:10.12095/j.issn.2095-6894.2018.09.008
中文关键词:  胃癌;靶向机制;药物;研究进展
英文关键词:Gastric cancer; Targeted mechanism; Drugs; Research progress
基金项目:1.广州中医药大学“薪火计划”项目(XH20170101);2.广东省中医药管理局(NO.2007058);3.青海省青藏高原植物化学重点实验室(2015-Z-Y09);4.国家自然科学基金青年项目(81102674)
作者单位E-mail
杨巧红 广州中医药大学基础医学院 qiaohong.yang@qq.com 
张新江 广州中医药大学第四临床医学院  
杜清 青海民族大学药学院;  
李琳琳 郑州大学第一附属医院肿瘤科  
蓝华全 广州中医药大学基础医学院  
吕依扬 广州中医药大学基础医学院  
黄舒蕾 广州中医药大学基础医学院  
印明柱 中南大学湘雅医院肿瘤科  
魏小勇 广州中医药大学基础医学院 wxyaby@gzucm.edu.cn 
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全文下载次数: 14
中文摘要:
      【】胃癌是全球范围内最常见的恶性肿瘤,常采用传统手术结合生物药物技术手段治疗胃癌。随着肿瘤生物学的快速发展,肿瘤分子标志物不断涌现,分子靶向治疗因其特异性强、副作用小等优势得到迅速发展,应用药物治疗肿瘤也在不断发展,显示出不可替代的优势。靶向治疗在胃癌中的研究也备受关注,但因其耐药性和分子标志物的缺乏等问题导致临床应用受限。通过总结分析常见的胃癌靶向治疗机制,阐述药物在临床中治疗胃癌的研究进展,为进一步明确靶向治疗胃癌的途径和方法提供借鉴意义。
英文摘要:
      【ABSTRACT】Gastric cancer is one of the most common malignant tumors in the world, and it has been treated by compounding the traditional technology and biological drug technology.?With the rapid development of tumor biology and the discovery?of tumor molecular markers, molecular targeted therapy has been rapidly developed because of its strong specificity and small side effects . Targeted therapies in gastric cancer are also of great concern and lead to the limited use of clinical application due to the drug resistance and the lack of effective molecular markers etc. The anti tumor research of traditional Chinese medicine is also developing and show an irreplaceable advantage. This article summaries and analyzes the action mechanism of common gastric cancer targeted treatment, moreover, stating the research progress of drugs in the treatment of gastric cancer in order to elucidate the targeted treatment pathway and method of gastric cancer.
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